Technology

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TECHNOLOGY

CUTTING EDGES TECHNOLOGIES FOR BIOLOGICAL ENGINEERING

Alderys’s innovation and savoir-faire is based on specialised development of extremely leading-edge technology in the domains of biological engineering, molecular improvement of enzymatic catalysts, and the development of microbial populations. The company has  designed and developed 3 principal technological platforms, one for each of the domains. These 3 platforms, complementary and under constant improvement, give Alderys a long-term competitive advantage. The company has also developed its own genome assembly software interfaced with numerous databases.

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> G-DESIGNER™

At the heart of Alderys’s technological lead, G-DESIGNER™ is the company’s genome engineering platform, dedicated to yeast genome engineering. On top of specific molecular tools and libraries, the platform combines various technologies developed by the company:

MGI, a massive gene modification technology which allows several combinations of dozens of genes to be assembled concurrently.  These can then be tested to find the best combinations for the production of interesting molecules. With MGI, the company researchers can investigate together in one step all the genes of a metabolic pathway or a significant section of a complex pathway. MGI is a technique for accelerating the assembly of new biosynthesis pathways.
TRAC and TRAC2 are two technologies developed specifically by Alderys.  They allow the massive expression, in a unique manner, of an enzyme which has been shown to be of critical importance to a procedure.
MCS  is a metabolic flux modification technology  which can redirect certain metabolic pathways and optimise the energy and redox equilibria in the cells.

Thanks to the G-DESIGNER™ platform, Alderys’s teams are able to construct over 450 new yeast and microbe strains per quarter.

> GENOSOFT™

Developed in 2010 and continually enriched with new functions, the GENOSOFT™ software is one of the company’s major assets. It optimises the design and automises numerous stages of the genome engineering implemented by Alderys. It facilitates the manipulation and semi-automatic assembly of large genome fragments. This software package furnishes the researchers with a collection of decision making tools which allows the real-time sharing of information. GENOSOFT™ is interfaced with the company’s biological collections and numerous scientific databases. This innovative software solution adds reliability to all the genome engineering operations carried out by our researchers and ensures their traceability.

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> SPRINT-CATALYST™

Enzymes, biological catalysts of metabolic reactions, are the major actors in every biosynthesis pathway. An efficient biosynthesis, compatible with industrial exploitation, requires catalysts which exhibit maximum efficiency in even one cell.

Alderys’s researchers have combined their savoir-faire in structural biology, enzymology and molecular biology to develop systems for the speedy discovery and improvement of enzymatic catalysts. SPRINT-CATALYST™ has the ability to create catalysts that are optimally adapted for the cellular environment in which they operate. To do this, SPRINT-CATALYST™ is built on automised, targeted processes which ensure, using a combinatorial approach, the identification of the best possible enzymes necessary for the synthesis of economically interesting compounds.

> EVOLEV™

EVOLEV™ combines robotic procedures developed by Alderys, specific selection algorithms and large data set visualisation tools. This platform is dedicated to the controlled evolution of microbe populations. EVOLEV™ facilitates the improvement of the strains developed without genetic manipulation. EVOLEV™ reproduces the natural processes of evolution in the laboratory. It can manage a wide range of different microbial strains, including strains already used in industry and those developed by the company. An expert system ensures the tracking of the evolution of the microbe populations and the automatic adaptation of the culture conditions for a number of months. EVOLEV’s advanced robotisation assures the traceability, continuity and safety of the evolution process.